/* ── Custom Properties ─────────────────────────────────── */
:root {
  --font-body: 'IBM Plex Mono', 'SF Mono', 'Menlo', monospace;
  --font-heading: 'IBM Plex Mono', 'SF Mono', 'Menlo', monospace;
  --font-mono: 'IBM Plex Mono', 'SF Mono', 'Menlo', monospace;

  --color-bg: #f4f4f6;
  --color-surface: #ffffff;
  --color-border: #e5e5e5;
  --color-border-light: #f0f0f0;
  --color-text: #1a1a1a;
  --color-text-secondary: #6b6b6b;
  --color-text-muted: #999999;
  --color-accent: #2563eb;
  --color-accent-light: #dbeafe;
  --color-accent-hover: #1d4ed8;
  --color-error: #dc2626;
  --color-error-bg: #fef2f2;
  --color-skeleton: #e5e5e5;
  --color-skeleton-shine: #f5f5f5;
  --color-hover-row: #f9fafb;

  --shadow-sm: 0 1px 2px rgba(0, 0, 0, 0.04);
  --shadow-md: 0 1px 3px rgba(0, 0, 0, 0.06), 0 1px 2px rgba(0, 0, 0, 0.04);
  --shadow-lg: 0 4px 6px rgba(0, 0, 0, 0.05), 0 2px 4px rgba(0, 0, 0, 0.03);

  --radius: 4px;
  --container-width: 960px;
}

/* ── Reset & Base ──────────────────────────────────────── */
*, *::before, *::after {
  box-sizing: border-box;
  margin: 0;
  padding: 0;
}

html {
  font-size: 16px;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
}

body {
  font-family: var(--font-body);
  color: var(--color-text);
  background: var(--color-bg);
  line-height: 1.6;
  min-height: 100vh;
  display: flex;
  flex-direction: column;
}

a {
  color: var(--color-accent);
  text-decoration: none;
}

a:hover {
  text-decoration: underline;
}

/* ── Layout ────────────────────────────────────────────── */
.container {
  max-width: var(--container-width);
  margin: 0 auto;
  padding: 0 24px;
  width: 100%;
}

.hidden {
  display: none !important;
}

/* ── Header ────────────────────────────────────────────── */
.site-header {
  padding: 48px 0 24px;
  text-align: center;
}

.site-title {
  font-family: var(--font-heading);
  font-size: 1.75rem;
  font-weight: 600;
  letter-spacing: 0.04em;
  text-transform: uppercase;
  color: var(--color-text);
  margin-bottom: 4px;
}

.site-subtitle {
  font-size: 0.95rem;
  color: var(--color-text-secondary);
}

/* ── Search ────────────────────────────────────────────── */
.search-section {
  margin-bottom: 32px;
}

.search-form {
  max-width: 480px;
  margin: 0 auto;
}

.search-field-group {
  display: flex;
  flex-direction: column;
  gap: 4px;
}

.search-label {
  font-family: var(--font-heading);
  font-size: 0.7rem;
  font-weight: 600;
  letter-spacing: 0.04em;
  text-transform: uppercase;
  color: var(--color-text-muted);
}

.search-input {
  font-family: var(--font-mono);
  font-size: 0.95rem;
  padding: 10px 14px;
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  background: var(--color-surface);
  color: var(--color-text);
  outline: none;
  transition: border-color 0.15s;
  width: 100%;
}

.search-input:focus {
  border-color: var(--color-accent);
  box-shadow: 0 0 0 3px var(--color-accent-light);
}

.search-input::placeholder {
  color: var(--color-text-muted);
}

.search-position-row {
  display: flex;
  gap: 8px;
}

.search-position-row .search-input {
  flex: 1;
}

.search-select {
  font-family: var(--font-mono);
  font-size: 0.9rem;
  padding: 10px 12px;
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  background: var(--color-surface);
  color: var(--color-text);
  outline: none;
  cursor: pointer;
  transition: border-color 0.15s;
}

.search-select:focus {
  border-color: var(--color-accent);
  box-shadow: 0 0 0 3px var(--color-accent-light);
}

.search-or {
  text-align: center;
  padding: 8px 0;
  font-size: 0.78rem;
  color: var(--color-text-muted);
  position: relative;
}

.search-or span {
  background: var(--color-bg);
  padding: 0 10px;
  position: relative;
  z-index: 1;
}

.search-or::before {
  content: '';
  position: absolute;
  left: 20%;
  right: 20%;
  top: 50%;
  height: 1px;
  background: var(--color-border);
}

.search-button {
  font-family: var(--font-heading);
  font-size: 0.85rem;
  font-weight: 500;
  letter-spacing: 0.03em;
  text-transform: uppercase;
  padding: 10px 24px;
  width: 100%;
  margin-top: 12px;
  background: var(--color-accent);
  color: #ffffff;
  border: none;
  border-radius: var(--radius);
  cursor: pointer;
  transition: background 0.15s;
  white-space: nowrap;
}

.search-button:hover {
  background: var(--color-accent-hover);
}

.search-button:disabled {
  opacity: 0.6;
  cursor: not-allowed;
}

.search-examples {
  text-align: center;
  margin-top: 10px;
  font-size: 0.85rem;
  color: var(--color-text-muted);
}

.example-link {
  font-family: var(--font-mono);
  font-size: 0.82rem;
}

.search-examples .sep {
  margin: 0 4px;
  color: var(--color-border);
}

/* ── Variant Card ──────────────────────────────────────── */
.variant-card {
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  box-shadow: var(--shadow-md);
  margin-bottom: 24px;
  overflow: hidden;
}

.variant-card-identity {
  padding: 14px 20px;
}

.variant-card-links {
  display: flex;
  gap: 16px;
  margin-top: 8px;
  font-size: 0.8rem;
}

.variant-card-section {
  padding: 12px 20px;
  border-top: 1px solid var(--color-border-light);
  min-height: 0;
}

.variant-card-section:empty {
  display: none;
}

.summary-card {
  display: flex;
  align-items: center;
  gap: 8px;
  flex-wrap: wrap;
  font-family: var(--font-mono);
  font-size: 0.9rem;
}

.summary-rsid {
  font-weight: 600;
  color: var(--color-accent);
}

.summary-sep {
  color: var(--color-border);
}

.summary-position {
  color: var(--color-text-secondary);
  font-size: 0.82rem;
}

.summary-alleles {
  color: var(--color-text);
}

.summary-gene {
  background: var(--color-accent-light);
  color: var(--color-accent);
  padding: 2px 8px;
  border-radius: 3px;
  font-size: 0.82rem;
  font-weight: 500;
  margin-left: 4px;
}

.summary-build-label {
  font-size: 0.7rem;
  font-weight: 600;
  letter-spacing: 0.04em;
  text-transform: uppercase;
  color: var(--color-text-muted);
}

/* ── Section Nav ───────────────────────────────────────── */
.section-nav {
  display: flex;
  gap: 0;
  border-bottom: 1px solid var(--color-border);
  margin-bottom: 24px;
  overflow-x: auto;
  position: sticky;
  top: 0;
  z-index: 100;
  background: var(--color-bg);
  transition: box-shadow 0.15s;
}

.section-nav.stuck {
  box-shadow: var(--shadow-md);
}

.nav-tab {
  font-family: var(--font-heading);
  font-size: 0.8rem;
  font-weight: 500;
  letter-spacing: 0.03em;
  text-transform: uppercase;
  padding: 10px 20px;
  color: var(--color-text-secondary);
  border-bottom: 2px solid transparent;
  transition: color 0.15s, border-color 0.15s;
  text-decoration: none;
  white-space: nowrap;
}

.nav-tab:hover {
  color: var(--color-text);
  text-decoration: none;
}

.nav-tab.active {
  color: var(--color-accent);
  border-bottom-color: var(--color-accent);
}

/* ── Result Sections ───────────────────────────────────── */
.results-container {
  display: flex;
  flex-direction: column;
  gap: 32px;
  margin-bottom: 48px;
}

.result-section {
  background: var(--color-surface);
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  box-shadow: var(--shadow-md);
  overflow: hidden;
}

.section-header {
  display: flex;
  align-items: center;
  justify-content: space-between;
  padding: 14px 20px;
  border-bottom: 1px solid var(--color-border-light);
  flex-wrap: wrap;
  gap: 8px;
}

.section-title {
  font-family: var(--font-heading);
  font-size: 0.85rem;
  font-weight: 600;
  letter-spacing: 0.04em;
  text-transform: uppercase;
  color: var(--color-text);
}

.section-meta {
  display: flex;
  align-items: center;
  gap: 12px;
}

.source-badge {
  font-family: var(--font-heading);
  font-size: 0.7rem;
  font-weight: 500;
  letter-spacing: 0.03em;
  text-transform: uppercase;
  padding: 3px 8px;
  background: var(--color-accent-light);
  color: var(--color-accent);
  border-radius: 3px;
  text-decoration: none;
  transition: background 0.15s;
}

a.source-badge:hover {
  background: #c7d8f8;
  text-decoration: none;
}

.source-link {
  font-size: 0.8rem;
}

.section-content {
  padding: 16px 20px;
  min-height: 80px;
}

/* ── Skeleton Loading ──────────────────────────────────── */
.skeleton-table {
  display: flex;
  flex-direction: column;
  gap: 12px;
}

.skeleton-row {
  height: 18px;
  background: linear-gradient(
    90deg,
    var(--color-skeleton) 25%,
    var(--color-skeleton-shine) 50%,
    var(--color-skeleton) 75%
  );
  background-size: 200% 100%;
  animation: skeleton-shimmer 1.5s ease-in-out infinite;
  border-radius: 3px;
}

.skeleton-row:nth-child(1) { width: 100%; }
.skeleton-row:nth-child(2) { width: 92%; }
.skeleton-row:nth-child(3) { width: 96%; }
.skeleton-row:nth-child(4) { width: 88%; }
.skeleton-row:nth-child(5) { width: 90%; }

@keyframes skeleton-shimmer {
  0% { background-position: 200% 0; }
  100% { background-position: -200% 0; }
}

/* ── Tables ────────────────────────────────────────────── */
.table-controls {
  display: flex;
  gap: 8px;
  margin-bottom: 12px;
  flex-wrap: wrap;
}

.table-filter-input {
  font-family: var(--font-mono);
  font-size: 0.75rem;
  padding: 6px 10px;
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  background: var(--color-bg);
  color: var(--color-text);
  outline: none;
  flex: 1;
  min-width: 160px;
}

.table-filter-input:focus {
  border-color: var(--color-accent);
}

.table-filter-select {
  font-family: var(--font-mono);
  font-size: 0.75rem;
  padding: 6px 10px;
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  background: var(--color-bg);
  color: var(--color-text);
  outline: none;
  cursor: pointer;
}

.table-wrapper {
  overflow-x: auto;
  -webkit-overflow-scrolling: touch;
}

.data-table {
  width: 100%;
  border-collapse: collapse;
  font-size: 0.75rem;
}

.data-table th {
  font-family: var(--font-heading);
  font-size: 0.68rem;
  font-weight: 600;
  letter-spacing: 0.04em;
  text-transform: uppercase;
  color: var(--color-text-secondary);
  text-align: left;
  padding: 8px 10px;
  border-bottom: 2px solid var(--color-border);
  white-space: nowrap;
  cursor: pointer;
  user-select: none;
  position: relative;
}

.data-table th:hover {
  color: var(--color-text);
}

.data-table th .sort-indicator {
  margin-left: 4px;
  font-size: 0.7rem;
  color: var(--color-text-muted);
}

.data-table th .sort-indicator.active {
  color: var(--color-accent);
}

.data-table td {
  padding: 7px 10px;
  border-bottom: 1px solid var(--color-border-light);
  vertical-align: top;
}

.data-table tbody tr:hover {
  background: var(--color-hover-row);
}

.data-table tbody tr:last-child td {
  border-bottom: none;
}

/* Numeric cells */
.data-table td.num {
  font-family: var(--font-mono);
  font-size: 0.72rem;
  text-align: right;
  white-space: nowrap;
}

.data-table th.num {
  text-align: right;
}

/* Significant p-values */
.pval-significant {
  color: var(--color-accent);
  font-weight: 600;
}

/* ── Show More Button ──────────────────────────────────── */
.show-more-wrapper {
  text-align: center;
  padding: 12px 0 4px;
}

.show-more-button {
  font-family: var(--font-heading);
  font-size: 0.78rem;
  letter-spacing: 0.03em;
  text-transform: uppercase;
  padding: 6px 16px;
  background: none;
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  color: var(--color-text-secondary);
  cursor: pointer;
  transition: border-color 0.15s, color 0.15s;
}

.show-more-button:hover {
  border-color: var(--color-accent);
  color: var(--color-accent);
}

/* ── Gene Pills ────────────────────────────────────────── */
.gene-pills {
  display: flex;
  flex-wrap: wrap;
  gap: 6px;
  margin-bottom: 16px;
}

.gene-pill {
  font-family: var(--font-mono);
  font-size: 0.8rem;
  font-weight: 500;
  padding: 4px 12px;
  border: 1px solid var(--color-border);
  border-radius: 20px;
  color: var(--color-text-secondary);
  cursor: pointer;
  transition: all 0.15s;
  background: none;
}

.gene-pill:hover,
.gene-pill.active {
  background: var(--color-accent-light);
  border-color: var(--color-accent);
  color: var(--color-accent);
}

/* ── Annotation Cards ──────────────────────────────────── */
.annotation-panels {
  display: flex;
  gap: 16px;
}

.annotation-panels > .annotation-card {
  flex: 1;
  min-width: 0;
  margin-bottom: 0;
}

.annotation-card {
  padding: 12px 16px;
  border: 1px solid var(--color-border-light);
  border-radius: var(--radius);
  background: var(--color-bg);
  margin-bottom: 12px;
}

.annotation-card-title {
  font-family: var(--font-heading);
  font-size: 0.72rem;
  font-weight: 600;
  letter-spacing: 0.04em;
  text-transform: uppercase;
  color: var(--color-text-muted);
  margin-bottom: 6px;
}

.annotation-card-value {
  font-family: var(--font-mono);
  font-size: 0.88rem;
  color: var(--color-text);
  word-break: break-all;
}

.annotation-card-value .consequence-tag {
  display: inline-block;
  font-size: 0.78rem;
  padding: 2px 6px;
  background: var(--color-accent-light);
  color: var(--color-accent);
  border-radius: 3px;
  margin: 2px 2px 2px 0;
}

.consequence-highlight {
  display: flex;
  align-items: center;
  gap: 6px;
  padding: 6px 10px;
  background: var(--color-accent-light);
  border: 1px solid #bdd4f7;
  border-radius: var(--radius);
  margin-bottom: 8px;
  font-family: var(--font-mono);
  font-size: 0.82rem;
  color: var(--color-accent);
  font-weight: 600;
}

.consequence-highlight .consequence-gene {
  color: var(--color-text);
}

/* Allele frequency bars */
.freq-bar-container {
  display: flex;
  align-items: center;
  gap: 8px;
  margin: 3px 0;
  font-size: 0.82rem;
}

.freq-bar-label {
  min-width: 110px;
  font-size: 0.78rem;
  color: var(--color-text-secondary);
  white-space: nowrap;
}

.freq-bar-track {
  flex: 1;
  height: 8px;
  background: var(--color-border-light);
  border-radius: 4px;
  overflow: hidden;
}

.freq-bar-fill {
  height: 100%;
  background: var(--color-accent);
  border-radius: 4px;
  transition: width 0.3s ease;
}

.freq-bar-value {
  font-family: var(--font-mono);
  font-size: 0.78rem;
  min-width: 48px;
  text-align: right;
  color: var(--color-text-secondary);
}

/* ── VEP Score Badges ─────────────────────────────────── */
.vep-badges {
  display: flex;
  flex-wrap: wrap;
  gap: 6px;
}

.vep-badge {
  display: inline-flex;
  align-items: center;
  gap: 5px;
  font-family: var(--font-mono);
  font-size: 0.75rem;
  padding: 4px 10px;
  border: 1px solid var(--color-border);
  border-radius: 20px;
  background: var(--color-bg);
  color: var(--color-text);
  cursor: default;
  white-space: nowrap;
}

.vep-badge.unavailable {
  opacity: 0.4;
}

.vep-badge.benign {
  border-color: #86efac;
  background: #f0fdf4;
}

.vep-badge.pathogenic {
  border-color: #fca5a5;
  background: #fef2f2;
}

.vep-badge.ambiguous {
  border-color: #fde68a;
  background: #fefce8;
}

.vep-badge-name {
  font-size: 0.65rem;
  font-weight: 600;
  letter-spacing: 0.03em;
  text-transform: uppercase;
  color: var(--color-text-muted);
}

.vep-badge-value {
  font-weight: 600;
}

/* ── Error / Empty States ──────────────────────────────── */
.error-banner {
  max-width: var(--container-width);
  margin: 24px auto;
  padding: 14px 20px;
  background: var(--color-error-bg);
  border: 1px solid var(--color-error);
  border-radius: var(--radius);
  color: var(--color-error);
  font-size: 0.9rem;
}

.section-error {
  display: flex;
  align-items: center;
  gap: 12px;
  padding: 12px 0;
  color: var(--color-text-secondary);
  font-size: 0.88rem;
}

.section-error .error-message {
  flex: 1;
}

.retry-button {
  font-family: var(--font-heading);
  font-size: 0.75rem;
  letter-spacing: 0.03em;
  text-transform: uppercase;
  padding: 5px 12px;
  background: none;
  border: 1px solid var(--color-border);
  border-radius: var(--radius);
  color: var(--color-text-secondary);
  cursor: pointer;
  transition: border-color 0.15s, color 0.15s;
  white-space: nowrap;
}

.retry-button:hover {
  border-color: var(--color-accent);
  color: var(--color-accent);
}

.empty-state {
  text-align: center;
  padding: 24px 0;
  color: var(--color-text-muted);
  font-size: 0.9rem;
}

/* ── Loading spinner (inline) ──────────────────────────── */
.spinner {
  display: inline-block;
  width: 16px;
  height: 16px;
  border: 2px solid var(--color-border);
  border-top-color: var(--color-accent);
  border-radius: 50%;
  animation: spin 0.6s linear infinite;
}

@keyframes spin {
  to { transform: rotate(360deg); }
}

/* ── Footer ────────────────────────────────────────────── */
.site-footer {
  margin-top: auto;
  padding: 32px 0;
  text-align: center;
  font-size: 0.82rem;
  color: var(--color-text-muted);
  border-top: 1px solid var(--color-border-light);
}

.site-footer p {
  margin-bottom: 4px;
}

.site-footer a {
  color: var(--color-text-secondary);
}

.site-footer a:hover {
  color: var(--color-accent);
}

/* ── Responsive ────────────────────────────────────────── */
@media (max-width: 640px) {
  .site-header {
    padding: 32px 0 16px;
  }

  .site-title {
    font-size: 1.4rem;
  }

  .search-position-row {
    flex-direction: column;
  }

  .summary-card {
    font-size: 0.82rem;
  }

  .variant-card-identity {
    padding: 12px 14px;
  }

  .variant-card-section {
    padding: 10px 14px;
  }

  .section-nav {
    gap: 0;
  }

  .nav-tab {
    padding: 8px 12px;
    font-size: 0.75rem;
  }

  .section-header {
    flex-direction: column;
    align-items: flex-start;
  }

  .annotation-panels {
    flex-direction: column;
  }

  .freq-bar-label {
    min-width: 80px;
    font-size: 0.7rem;
  }

  .section-content {
    padding: 12px 14px;
  }

  .data-table {
    font-size: 0.7rem;
  }

  .data-table th,
  .data-table td {
    padding: 6px 8px;
  }
}